The following is a partial list of books and scientific papers that you might find helpful in learning more about some of the ideas and concepts expressed in the book. This is by no means an exhaustive list, but it will get you started in embracing a new perspective and living up to the principles of The End of Illness. These materials can also open other doors for further research and inquiry. This list is constantly being updated; for corrections and additional notes of reference to the current edition of the book, please refer to the last section of this listing.
Agus, D.B. et al. Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters. Journal of Clinical Investigation 100, no. 11 (1997): 2842–48.
Agus, D.B., J. Vera, and D. Golde. Stromal cell oxidation: A mechanism by which tumors obtain vitamin C. Cancer Research 59, no. 18 (1999): 4555–58. Armstrong, L. It’s Not About the Bike: My Journey Back to Life. New York: Berkley, 2001.
Atkinson, G., and L. Speirs. Diurnal variation in tennis service. Perceptual & Motor Skills 86, no. 3 pt. 2 (June 1998): 1335–38.
Baxter, C., and T. Reilly. Influence of time of day on all-out swimming. British Journal of Sports Medicine 17, no. 2 (June 1983): 122–27.
Bishop, D. The effects of travel on team performance in the Australian national netball competition. Journal of Sports Science and Medicine 7, no. 1 (March 2004): 118–22.
Bjelakovic, G., D. Nikolova, L.L. Gluud, R.G. Simonetti, and C. Gluud. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. Journal of the American Medical Association 297, no. 8 (February 28, 2007): 842–57.
Blair, S.N. Physical inactivity: the biggest public health problem of the 21st century. British Journal of Sports Medicine 43, no. 1 (January 2009): 1–2.
Blair, S.N., et al. A tribute to Professor Jeremiah Morris: the man who invented the field of physical activity epidemiology. Annals of Epidemiology 20, no. 9 (September 2010): 651–60.
Breus, M. Good Night: The Sleep Doctor’s 4-Week Program to Better Sleep and Better Health. New York: Dutton, 2006.
Breus, M. The Sleep Doctor’s Diet Plan: Lose Weight through Better Sleep. Emmaus: Rodale, 2011.
Carney, C.E., J.D. Edinger, B. Meyer, L. Lindman, and T. Istre. Daily activities and sleep quality in college students. Chronobiology International 23, no. 3: 623–37.
Center, J.R., D. Bliuc, N.D. Nguyen, T.V. Nguyen, and J.A. Eisman. Osteoporosis medication and reduced mortality risk in elderly women and men. Journal of Clinical Endocrinology & Metabolism 96, no. 4 (April 2011): 1006–14. Epub February 2, 2011.
Copinschi, G. Metabolic and endocrine effects of sleep deprivation. Essential Psychopharmacology 6, no. 6 (2005): 341–47.
de Lorgeril, M., et al. Cholesterol lowering, cardiovascular diseases, and the rosuvastatin-JUPITER controversy: a critical reappraisal. Archives of Internal Medicine 170, no. 12 (June 28, 2010): 1032–36.
Dreyfuss, J.H. Oral bisphosphonate use associated with a decreased risk of breast cancer. CA—A Cancer Journal for Clinicians 60, no. 6 (November-December 2010): 343–44. Epub October 19, 2010.
Edwards, B.J., W. Edwards, J. Waterhouse, G. Atkinson, and T. Reilly. Can cycling performance in an early morning, laboratory-based cycle time-trial be improved by morning exercise the day before? International Journal of Sports Medicine 26, no. 8 (October 2005): 651–6. Erratum in: Journal of the American College of Cardiology 57, no.16 (April 19, 2011): 1717.
FDA website: http://www.fda.gov/food/foodsafety/product-specificinforma tion/seafood/foodbornepathogenscontaminants/methylmercury/ucm115644.htm.
Forrester, D.P. Consider: Harnessing the Power of Reflective Thinking in Your Organization. New York: Palgrave Macmillan, 2011.
Freedman, D.M., A.C. Looker, C.C. Abnet, M.S. Linet, and B.I. Graubard. Serum 25-hydroxyvitamin D and cancer mortality in the NHANES III study (1988–2006). Cancer Research 70, no. 21 (November 1, 2010): 8587–97. Epub September 16, 2010.
Garry, A., D.H. Edwards, I.F. Fallis, R.L. Jenkins, and T.M. Griffith. Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide. Cardiovascular Research 84, no. 2 (November 1, 2009): 218–26. Epub July 10, 2009.
Gershon, M. The Second Brain: The Scientific Basis of Gut Instinct and a Groundbreaking New Understanding of Nervous Disorders of the Stomach and Intestines. New York: HarperCollins, 1998.
Ginsberg, J., et al. Detecting influenza epidemics using search engine query data. Nature 457, no. 7232 (February 2009): 1012–14.
Gnant, M., et al. Endocrine therapy plus zoledronic acid in premenopausal breast cancer. New England Journal of Medicine 360, no. 7 (2009): 679–91.
Green, R.C., et al. Disclosure of APOE genotype for risk of Alzheimer’s disease. New England Journal of Medicine 361, no. 3 (July 16, 2009): 245–54.
Guevara-Aguirre, J., et al. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Science Translational Medicine 3, no. 70 (February 16, 2011): 70ra13.
Haldane, J.B.S. Daedalus, or Science and the Future. A paper read to the Heretics, Cambridge, UK, February 4, 1923. Transcribed by CR Shalizi, April 10, 1993, Berkeley, CA. Source: http://www.cscs.umich.edu/~crshalizi/daedalus.html.
Hillis, D. TED talk, 2010. Understanding Cancer through Proteomics. Accessed on October 18, 2011. http://www.ted.com/talks/danny_hillis_two_frontiers_of_cancer_treatment.html.
Jablonski, N.G., and G. Chaplin. Colloquium Paper: Human skin pigmentation as an adaptation to UV radiation. Proceedings of the National Academy of Sciences 107, Suppl. 2 (May 11, 2010): 8962–68.
Jehue, R., D. Street, and R. Huizenga. Effect of time zone and game time changes on team performance: National Football League. Medicine & Science in Sports & Exercise 25, no. 1 (January 1993): 127–31.
Kirsh, V.A., et al. Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostate cancer risk. Journal of the National Cancer Institute 98, no. 4 (February 15, 2006): 245–54.
Klein, E.A., et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Journal of the American Medical Association 306, no. 14 (October 12, 2011): 1549–56.
Levitt, S.D., and S.L. Dubner. Freakonomics: A Rogue Economist Explores the Hidden Side of Everything. New York: William Morrow, 2006.
Lind, J. A Treatise on the Scurvy. Nabu Press, 2011; originally published in 1753.
Manber, R., R.R. Bootzin, C. Acebo, M.A. Carskadon. The effects of regularizing sleep-wake schedules on daytime sleepiness. Sleep 19, no. 5 (June 1996): 432–41.
Martí, O., and A. Armario. Influence of regularity of exposure to chronic stress on the pattern of habituation of pituitary-adrenal hormones, prolactin and glucose. Stress 1, no. 3 (May 1997): 179–89.
Miller, E.R., 3rd, et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Annals of Internal Medicine 142, no. 1 (January 4, 2005): 37–46. Epub November 10, 2004.
Morris, J.N., and M.D. Crawford. Coronary heart disease and physical activity of work: evidence of a national necropsy survey. BMJ 2 (December 20, 1958): 1485–96.
Morris, J.N., J.A. Heady, P.A.B. Raffle, C.G. Roberts, and J.W. Parks. Coronary heart-disease and physical activity of work. Lancet 265, no. 6795 (November 21, 1953): 1053–57.
Morris, J.N., J.A. Heady, P.A.B. Raffle, C.G. Roberts, and J.W. Parks. Coronary heart-disease and physical activity of work. Lancet 262 (November 28, 1953): 1111–20.
Mukherjee, S. The Emperor of All Maladies: A Biography of Cancer. New York: Scribner, 2010.
Neuhouser, M.L., et al. Multivitamin use and risk of cancer and cardiovascular disease in the Women’s Health Initiative cohorts. Archives of Internal Medicine 169, no. 3 (February 9, 2009): 294–304.
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Reardon, D.A., et al. A review of VEGF/VEGFR-targeted therapeutics for recurrent glioblastoma. Journal of the National Comprehensive Cancer Network 9, no. 4 (April 2011): 414–27.
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Ridker, P.M.; JUPITER Study Group. Rosuvastatin in the primary prevention of cardiovascular disease among patients with low levels of low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: rationale and design of the JUPITER trial. Circulation 108, no. 19 (November 11, 2003): 2292–97.
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Sanders, K.M., et al. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. Journal of the American Medical Association 303, no. 18 (2010): 1815–22. doi: 10.1001/jama.2010.594.
Schrödinger, E. What Is Life? The Physical Aspect of the Living Cell. Cambridge, UK: Cambridge University Press, 1944.
Schürks, M., R.J. Glynn, P.M. Rist, C. Tzourio, and T. Kurth. Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ 341 (November 4, 2010): c5702. doi: 10.1136/bmj.c5702.
Sedliak, M., T. Finni, S. Cheng, W.J. Kraemer, and K. Häkkinen. Effect of time-of-day-specific strength training on serum hormone concentrations and isometric strength in men. Chronobiology International 24, no. 6 (2007): 1159–77.
Snowdon, D. Aging with Grace: What the Nun Study Teaches Us About Leading Longer, Healthier, and More Meaningful Lives. New York: Bantam, 2001.
Spiegel, K., et al. Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. Journal of Clinical Endocrinology & Metabolism 89, no. 11 (November 2004): 5762–71.
Stamatakis, E., M. Hamer, and D.W. Dunstan. Screen-based entertainment time, all-cause mortality, and cardiovascular events: population-based study with ongoing mortality and hospital events follow-up. Journal of the American College of Cardiology 57, no. 3 (January 18, 2011): 292–99.
Taheri, S., L. Lin, D. Austin, T. Young, and E. Mignot. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Medicine 1, no. 3 (December 2004): e62. Epub December 7, 2004.
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Virtamo, J., et al. Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. Journal of the American Medical Association 290, no. 4 (July 23, 2003): 476–85.
Vivekananthan, D.P., M.S. Penn, S.K. Sapp, A. Hsu, and E.J. Topol. Use of antioxidant vitamins for the prevention of cardiovascular disease: metaanalysis of randomised trials. Lancet 361, no. 9374 (June 14, 2003): 2017–23.
Wang, T.J., et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376, no. 9736 (July 17, 2010): 180–88. Epub June 10, 2010.
Zhang, W., et al. Index to ring finger length ratio and the risk of osteoarthritis. Arthritis & Rheumatism 58, no. 1 (January 2008): 137–44.
Page 163: I owe calling vitamins C a molecule that has an “alter ego” to Sam Wong of the British Heart Foundation who wrote a marvelous piece in an article for The Guardian following the 2009 Cardiff study published in Cardiovascular Research, which proved how vitamin C can have a split personality—acting as both an antioxidant and a pro-oxidant. For a vitamin that’s famous for its antioxidant qualities, there’s no better term than “alter ego” if it can also produce free radicals. Wong perfectly described how vitamin C—and perhaps other pro-oxidant molecules such as tetrahydrobiopterin, which was also studied by the Cardiff researchers—might one day help treat patients with cardiovascular disease.